In 1845 Montana, a Blackfoot Chief tries to buy a cure for his tribe's small-pox infection but the white settlers are unsympathetic forcing the Indian Chief to resort to desperate measures.
Smallpox plagues Chief Winterhawk's tribe. He seeks cure from the white men, who in turn, in fear of getting the smallpox, kill two of his companions. Winterhawk comes back to kidnap a girl and her brother from the white men's settlement, and thus begins the chase...